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If youre taking any medications, discuss B12 supplementation with your healthcare provider to rule out interactions
Some patients get paradoxical fatigue or headaches from B12 due to detoxification effects, in which case lower your dose
For most people, SQ shots are much less painful than IM shots because muscle tissue has a significantly higher density of nerve endings
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Clinically meaningful responses in insulin-resistant patients typically include a reduction in fasting insulin of 20-40% and an improvement in HOMA-IR within 8-12 weeks at therapeutic doses, though individual variability is wide [1]
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