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An experiment in mice also discovered that activation of central GLP-1R leads to downregulation of TNF gene expression, resulting in lower TNF- expression

Histopathology Complete histopathology was performed in 24-mo-old female [Old Con ( n = 16), and Old mAb ( n = 16)] and male mice [Old Con ( n = 15), and Old mAb ( n = 17)] following 6 mo of mAb treatment, as well as in female mice at death from the longevity study [Old Con ( n = 30), and Old mAb ( n = 20)]

Kerksick, C., Willoughby, D

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