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Reduced calorie diet combined with NNMT inhibition establishes a metabolic memory

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Unlike B12 deficiency, which produces recognisable neurological and haematological symptoms, excess vitamin B12 typically remains asymptomatic and is discovered incidentally during routine blood tests

The established maximum doses represent the upper limits studied in clinical trials, beyond which risk-benefit ratios become unfavorable

The nerve revival process, while beneficial, can feel strenuous for a short period

In experimental models it is used to explore mechanisms of tissue regeneration, angiogenesis, inflammatory modulation and maintenance of gastrointestinal barrier integrity