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[19] [20] [21] It is on the World Health Organization's List of Essential Medicines
& Segars, J
Metabolites 2023;14(1):12
McGovern AS, Hamlin AS, Winter G
half life 1.5-3 hours excreted by the kidney (no metabolism) Side Effects: Rare : dose-related incidence of lactic acidosis GI side effects (diarrhea, nausea, vomiting, abdominal bloating, gas, reduced appetite) (~20% of patients develop dose-related GI side effects) Vitamin B12 deficiency
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These concerns were initially based on biological evidence indicating that the incretin system and the GLP-1-receptor might play a role in the development of cholangiocarcinoma [5,6,7], and further highlighted by an observational study using data from the UK Clinical Practice Research Datalink [8] showing that use of DPP4 inhibitors, compared with other second- or third-line glucose-lowering drugs, was associated with an increased risk of cholangiocarcinoma (HR 1.77 [95% CI 1.04, 3.01])
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