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GLP-1 receptor agonists are designed to resist rapid enzymatic degradation, thereby allowing sustained receptor activation

Exogenous antioxidantsDouble-edged swords in cellular redox state: health beneficial effects at physiologic doses versus deleterious effects at high doses

These include mitogen-activated protein kinase and nuclear factor-B (NF-B), which lead to the expression of inflammatory cytokines, chemokines, and adhesion molecules

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Pharmacological advances in mitochondrial therapy

Melatonin is a well-studied sleep-timing hormone