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Sarwer DB, Hanson AJ, Voeller J, Steffen K

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Benefit: Gut Health Focus Area: Leaky Gut, IBD, Ulcers Mechanism of Action: Repairs the mucosal lining and maintains intestinal barrier integrity

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Moreover, because of its dual anti-inflammatory and antioxidative properties, nuclear factor erythroid-2-related factor 2/heme oxygenase-1 (Nrf2/HO-1) has been considered a critical signaling pathway that counteracts oxidative stress in MTX-induced intestinal injury