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420 However, KD may contribute to decreased sensitivity to peripheral insulin and impaired glucose tolerance by upregulating insulin receptors, as determined by previous studies, which contradicts clinical findings

The GLP-1 receptor agonist component increases insulin secretion and slows gastric emptying, which helps the patient feel full

Different types work in varying ways

Safety and efficacy of a GLP-1 and glucagon receptor dual agonist mazdutide (IBI362) 9 mg and 10 mg in Chinese adults with overweight or obesity: a randomised, placebo-controlled, multiple-ascending-dose phase 1b trial

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An 'enormous' cost The high price of GLP-1 drugs - which are patented, meaning cheaper copycat versions can't be made - has led to a debate among insurance companies, said Benjamin Rome, a health policy researcher at Harvard Medical School