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Patient-derived xenograft models were conducted in accordance with established guidelines, having obtained written consent from the respective patients, and received approval from the Second Xiangya Hospital of Central South University (2020591)
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In individuals homozygous for the C677T polymorphism in the MTHFR gene, low riboflavin status is associated with elevated plasma homocysteine, and in turn linked with a higher risk of cardiovascular disease and other chronic diseases (13, 14)
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