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Glucagon-like peptide-1 (GLP-1) receptor agonists are a class of medications primarily prescribed for type 2 diabetes management and, more recently, for chronic weight management

After gastric sleeve surgery 13 months ago, the special education assistant and mother of two successfully lost a significant amount of weightbut something still held her back

Patients were randomized 1:1:1:1 to survodutide 2.4, 4.8, or 6 mg weekly, or placebo for 48 weeks

Triple agonist at GLP-1R (appetite suppression), GIPR (insulin sensitization), and GCGR (hepatic lipolysis and energy expenditure)

Even adjusting for the different trial durations, the magnitude of difference is enormous

Transferrin receptor 1 is a supplementary receptor that assists transmissible gastroenteritis virus entry into porcine intestinal epithelium