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Cell Death Dis 5(6):e1299 Patil SP, Jain PD, Ghumatkar PJ, Tambe R, Sathaye S (2014) Neuroprotective effect of metformin in MPTP-induced Parkinsons disease in mice

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The activity of GPx decides production of GSSG, a precursor to GSH (Muthukumar et al., 2011)

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For a 180 pound individual, this represents approximately 2.5 mcg/kg, well within the range shown effective in animal studies