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Pre-incubation with the ApoE improved the uptake of the LNPs by LECs in the ApoE / mice
Consistent with this, FGF21 is induced by lipid accumulation in cardiomyocytes ( Nervous System The cytoprotective effects of FGF21, whether direct or indirect, are also evident in the nervous system, where FGF21 treatment attenuates neuroinflammation, neuronal oxidative stress, and neurodegeneration and preserves cognitive function in diabetic mice and high fat fed rats (270, 271)
[PMID: 7688530] PubMed record related to this compound for laboratory literature review
Modelling changes in glutathione homeostasis as a function of quinone redox metabolism
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