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A FAERS-based pharmacovigilance analysis comparing tirzepatide vs semaglutide in female reports (Q1 2022Q3 2025) reported gynaecological haemorrhagic events in 0.62% of semaglutide cases (204 cases among 32,839 female-specific reports in that analysis) and did not detect a disproportionate signal vs tirzepatide

Ipamorelin, even at doses 10x above the ED50, does not produce clinically meaningful elevations in ACTH, cortisol, prolactin, or aldosterone

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The median peak plasma tesamorelin concentration (Tmax) was 0.15 h in both populations