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Quercetagetin alleviates liver fibrosis in non-alcoholic fatty liver disease by promoting ferroptosis of hepatic stellate cells through GPX4 ubiquitination

Lentiviral-based transfection into HaCaT cells For suppression of NRF2 in HaCaT cells, lentiviral particles expressing shRNAs against human NRF2 were used to downregulate NRF2 mRNA

Excess iron can drive oxidative stress , essentially creating internal "rust", which damages cells, contributes to inflammation, and ironically impairs detoxification

We put forward the hypothesis of ferroptosis, a recently identified iron-dependent cell death, as a potential underlying mechanism of BD

Liu, and M