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Acknowledgements Reviewer information Nature Reviews Endocrinology thanks B
Switching from semaglutide to tirzepatide is one of the most common transitions when a stall persists, as the dual receptor mechanism can reignite weight loss even when single-receptor therapy has plateaued
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Semaglutide (Ozempic and Wegovy) and tirzepatide (Mounjaro and Zepbound) may reduce birth control effectiveness and may increase risk of birth defects if taken during pregnancy
Several of these medicines are now widely used for both type 2 diabetes and weight management
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