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These cells remain metabolically active, adopt a distinct phenotype (including chromatin changes), and critically secrete a variety of pro-inflammatory cytokines, proteases, growth-factors and extracellular-matrix modifying signals

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Analytically, a co-formulated vial also demands more of its certificate of analysis, which must resolve and assay two species of very different mass separately rather than reporting one aggregate figure

Some individuals develop a small area of redness or swelling at the injection site after IM administration

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