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These symptoms can overlap with and potentially worsen the gastrointestinal effects already associated with GLP-1 therapy, making it difficult to distinguish which agent is responsible for adverse effects

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the FDA has stated it lacks sufficient information to know whether the substance would cause harm when administered to humans Evidence snapshot: The evidence base is almost entirely preclinical, decades of animal (largely rat) studies, mostly from one Croatian research group (Sikiric et al., University of Zagreb), with a single small human trial under the brand name "Bepecin" (around 2015) that did not lead to any FDA-approved use

Early results from a small clinical trial look promising and they plan to begin a larger clinical trial later this year of GLP-1 drugs to treat opioid addiction in the outpatient setting

10.1016/j.ctim.2025.103161 18 CostaI.BarbosaD

How To Use 5 days per week before bed or before workout on an empty stomach