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Although the relative increase appears significant, the condition itself remains uncommon, which is why ophthalmologists focus on early recognition and prompt assessment rather than avoidance of an otherwise valuable treatment

Hauser RA, Lyons KE, McClain T, Carter S, Perlmutter D

Magnesium glycinate at 300 to 400 mg daily is the most effective supplement for muscle pain on tirzepatide, particularly for cramps and spasms

Although available in wellness settings, AOD-9604 is not FDA-approved and should be used strictly in research contexts

Employer Responses: To manage costs, employers are more likely to reduce coverage or shift costs to employees, with 56% of large employers planning cost-cutting measures for 2026 compared to 48% in 2025