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The people with chronic migraine starting GLP-1 drugs were compared to people with chronic migraine who were starting topiramate, a drug commonly used to prevent migraine

Why this matters for dosing The extended half-life means: Once-weekly injections are sufficient the drug does not need to be taken daily Steady-state levels build up over several weeks this is another reason why gradual titration works well

Starting supplementation : Consider introducing one supplement at a time, allowing 12 weeks to assess tolerance before adding the second

They can become very itchy

The same needle recommendations apply: 30G or 31G, 6 mm, fixed needle, low dead space insulin syringe

Both are brand-name semaglutide from Novo Nordisk