However, emerging research suggests that these drugs may come with an unexpected riskan increased incidence of ischemic optic neuropathy, a condition closely related to ischemic retinopathy
Instead, blocking GIP may: Reduce fat storage Enhanced weight loss and reduced body mass index (BMI) Offer metabolic and heart benefits Early data suggest this GIPR-blocking approach may help the body respond differently to calories, making it easier to continue losing weight without early plateaus
Who Tends to Maintain Weight Successfully After Stopping GLP-1s Patients who do best after discontinuation often share common factors: They taper slowly rather than stopping abruptly They rebuild hunger awareness while still on medication They prioritize adequate protein intake They preserve lean muscle through resistance training They address sleep, stress, and hormonal health They maintain medical follow-up during the transition This is not about perfection
Adherence to proper injection techniques and aseptic protocols is crucial to minimise the risk of adverse reactions
Because of the animal studies, it is contraindicated in those with medullary thyroid cancer or a history of multiple endocrine neoplasia syndrome
2024 PMID: 39226030