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In vitro studies have shown that epidermal vitiligo melanocytes have lower adenosine Triphopsphate (ATP), increased proton leakage, and altered expression of several glycolytic enzymes (hexokinase II, pyruvate dehydrogenase kinase 1, and pyruvate kinase M2) compared to healthy cells

doi: 10.1042/BJ20021371 95

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Both have a real limitation: inflammation and oxidative stress can push them around independently of selenium, so some experts question how reliably they identify deficiency

The resulting complex is water-soluble, allowing it to enter the bloodstream and be excreted harmlessly

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