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Primary outcomes Risk of colorectal cancer All seven included studies discussed the colorectal cancer risk as an outcome among patients receiving GLP-1 RAs
For the survival cohort study, Rosa26-creERT2 ;Gpx4 f/f mice were intraperitoneally treated with tamoxifen (Sigma-Aldrich, T2859, 2 mg per day dissolved in Myglyol 812) on days 0 and 1 for deletion of Gpx4 in the whole body except in the brain 2
PI3K/mTOR Axis Mediates GLP-1R Signalling Actions on Glucose Metabolism GLP-1 can regulate cell size, function and proliferation in -cells via PI3K/mTOR pathway 25, 26
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