In particular, USP22 raised GSH content and reduced the occurrence of ferroptosis in cardiomyocytes by activating the Sirt1-p53/SLC7A11 axis [252]
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Across corticosteroids, acetaminophen, NSAIDs, and opioids, a consistent pattern emerges: Inflammation is suppressed, but tissue repair is impaired Pain signals are blocked, but nervous system sensitivity increases Symptoms are quieted, but root causes remain unaddressed Over time, this creates a widening gap between symptom relief and true recovery