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Increased release of glutamate from presynaptic terminals activates N -methyl-D-aspartate (NMDA) receptors on postsynaptic terminals to lead to a widespread neuronal depolarization or spreading depression, further disrupting the sodium ion, potassium ion, and calcium ion equilibria (Langlois et al., 2006)

In addition to its crucial role in the management of diabetes, metformin shows promising clinical applications in anti-tumor therapy

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Ice crystal formation can physically damage the peptide structure

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