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Since synergy demands a higher standard than simple overlap, its evaluation requires comparisons between combinations and individual peptides, standardized injury models, and predefined evaluation criteria (migration assays, histology, collagen organization, vascular markers, inflammatory markers, and functional metrics)

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Researchers working with extended time courses should validate stability for their own assay conditions rather than assuming a fixed window

A lighter or leaner body receives more exposure per kilogram and may show a different balance of appetite, heart-rate, and lean-mass effects