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Polymorphisms in the MTHFR gene, an excess of methionine and SAM, or a low concentration of co-factor vitamin B2 can decrease MTHFR activity
For optimal results, patients should aim to consume a balanced mixture of both fibre types
& Pernow, J
Carboxypeptidase enzymes degrade unprotected GHK within hours of topical application, which is why encapsulation and formulation pH matter as much as concentration
Other poor predictors of outcome are old age, female sex, high AST
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