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A fully automated home cage for long-term continuous phenotyping of mouse cognition and behavior

Several factors: cancer biology concerns with c-Met activation, replication uncertainty, lack of corporate funding for development, and the difficulty of cognitive enhancement drug development generally

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Front-load calories earlier in the day when appetite tends to be slightly higher

B12 injections help protect the nervous system by promoting the production of myelin, the protective coating around nerves, which is crucial for proper signal transmission

Later increases are made in 2.5 mg steps after at least four weeks at the current dosage, with treatment response and tolerability guiding the maintenance choice