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Podocytes produce homeostatic chemokine stromal cell-derived factor-1/CXCL12, which contributes to glomerulo-sclerosis, podocyte loss and albuminuria in a mouse model of type 2 diabetes
Unlike many compounds targeting hormonal pathways, PT-141 works through the central nervous system, specifically activating melanocortin receptors involved in sexual response
Mar M., et al
Gehrig et al
The results demonstrated that MT2 administration improved social behavioral metrics, which had been impaired in the MIA mice
We then pre-incubated early ring-stage artemisinin resistant and sensitive parasites with BSO for 1 h prior to pulse treatment with 700 nM of DHA for 6 h and measured survival, analogous to the standard in vitro Ring-stage Survival Assay (RSA) for artemisinin resistance
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