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China Patent CN101921712 (B) Perricone C, Carolis C de, Perricone R (2009) Glutathione: a key player in autoimmunity

TGR inhibitors have efficacy as schistosomicidal agents in vivo Encouraged by the activity of our non-covalent TGR inhibitors against ex vivo worms, we evaluated the schistosomicidal activity of these compounds in mice infected with S

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and indirectly, as the essential co-substrate for glutathione peroxidase (GPx) and glutathione S-transferase (GST) enzymes that detoxify hydrogen peroxide, lipid peroxides, and electrophilic compounds