If you have diabetes or prediabetes and use semaglutide for both weight management and blood sugar control, monitor your glucose levels closely during the first few weeks after switching to a niacinamide compound
Seek immediate medical attention (A&E or call 999) if you develop: Severe, persistent abdominal pain radiating to the back (potential pancreatitis) Bloody or black, tarry stools Persistent vomiting with inability to keep down fluids Signs of severe dehydration or altered consciousness Symptoms of bowel obstruction (severe bloating, inability to pass gas or stool, severe cramping) For urgent but non-life-threatening concerns outside of GP hours, contact NHS 111 for advice
transient flushing or headache may occur
Coulter DL, Allen RJ: Secondary hyperammonaemia: a possible mechanism for valproate encephalopathy
Stellate cells, hepatocytes, and endothelial cells imprint the Kupffer cell identity on monocytes colonizing the liver macrophage niche
Whilst the UK advises that women using GLP-1 receptor agonists should avoid pregnancy and use effective contraception, this advice is not being followed consistently in Australian clinical practice, he said
