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Russell et al., 2019
The most common side effects are gastrointestinal, including nausea (15-30%), diarrhea (13-16%), vomiting (6-12%), and constipation (6-7%)
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247 Therefore, the exposure of osteoclasts to bisphosphonates leads to less bone resorption and lower release of bone-stored factors, breaking the vicious cycle between tumors and bone
Starting too high is the single most common mistake, and it leads to unnecessary gastrointestinal distress that could have been avoided with proper titration
Sunde RA, Evenson JK (2002) Control of gene expression of glutathione peroxidase-1 and other selenoproteins in rats and cultured cells
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