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Looking at adverse events of special interest, these were low and did not appear to be different between semaglutide and tirzepatide (Table 2)

However, it remains unclear whether vascular GLP-1 receptor expression changes under some conditions and which factors could affect vascular GLP-1 receptor expression

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To report suspected adverse reactions to Zepbound, contact the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch

doi:10.1007/s00125-019-04977-9 4

Maintaining stable blood sugar levels, achieving a healthy weight, and addressing any underlying conditions like PCOS are essential steps in promoting regular menstrual cycles for individuals with diabetes