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The rationale is that even sub-therapeutic doses activate the GLP-1 and GIP receptors enough to produce noticeable appetite modulation without the gastrointestinal side effects that trouble many users during standard initiation

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If you have pre-existing kidney problems or concerns about how tirzepatide may affect your kidneys, its essential to discuss this with your doctor

Acknowledgements The authors would like to thank the Stanford University Veterinary Service Center for their assistance and care of animals used in this study, and Ben Franco and Kaleigh Beacham for their support with collection of blood

one employer (enrollment began in February) had a limited number of prescriptions during this period