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7.3 Transgenerational and epigenetic research priorities While animal studies consistently demonstrate heritable reproductive dysfunction through EED-induced epigenetic modifications, human evidence remains limited, necessitating focused research initiatives to validate these mechanisms in human populations

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Additionally, the combined effects of oxidative stress and excitotoxicity activate both caspase-dependent and caspase-independent apoptotic pathways, leading to cellular fragmentation and neurodegeneration

Understanding their differences helps clarify their potential applications