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476 Oligodendrocyte differentiation and myelination are impaired by mtDNA damage and oxidative stress, leading to altered transcription, double-strand breaks, and mitochondrial deletion events, especially involving complex IV
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In animal models of diabetic nephropathy, a dose of curcumin equivalent to about 1.1 g for an adult human prevented the progression of renal disease (Trujillo 2013)
Mechanistically, necroptosis can be triggered by a variety of extracellular and intracellular danger signals, including tumor necrosis factor- (TNF-), Fas ligand, interferons, or Toll-like receptor (TLR) ligands (133)
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T., McConnell, A
