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It is notable for its remarkable stability compared to many other endogenous peptides

However, medical advice should be sought if periods stop for more than 90 days, become extremely heavy, or cause significant symptoms

Patients should receive comprehensive education regarding signs and symptoms that could indicate malignancy and should be counseled to report any new symptoms or changes promptly

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The clinical use track record in Eastern Europe and Asia provides a level of real-world safety and efficacy data that purely preclinical peptides lack, though large-scale randomized controlled trials specifically for peripheral neuropathy are still needed