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People who are pregnant or breastfeeding, those with kidney disease, seizure disorders, or thyroid conditions, and anyone on medications that could interact should avoid it unless a physician specifically approves it

A randomized, double-blind, placebo-controlled clinical trial to evaluate the efficacy and safety of neramexane in patients with moderate to severe subjective tinnitus

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and decreasing the expression of dynamin-related protein 1 (Drp1) and mitochondrial fission protein 1 (Fis1) [17]