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Response timelines vary considerably based on individual factors, but general patterns include weeks 1-4 with subtle energy improvements and enhanced recovery for many users, weeks 4-8 with more consistent energy benefits and early signs of improvements in areas such as skin appearance for some individuals, and weeks 8-12 and beyond with optimal benefits typically developing after 2-3 months of consistent therapy

[Abstract]2024 Nov 10;43(11):114915

PMID 19237716

This may include consumer health data

Why this is important: Reduced blood flow to the feet If a Vitamin B12 deficiency is causing a reduction or interrupted blood supply to the feet, you may experience very cold feet without reprieve, changes in skin colour (feet may appear white or purple), development of chilblains, muscle cramping and numbness

Dong, S