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New or Worsening Food Intolerances: Sealing the tight junctions prevents large, undigested food proteins from entering the bloodstream, which reduces the immune system's hyper-reactive antibody response to previously tolerated foods

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This raises potential concerns for patients with pancreatic and gastrointestinal neuroendocrine cancer or those with genetic conditions like multiple endocrine neoplasia syndrome (MEN1), which predispose individuals to NENs

A $50 product at 200 mg per serving with 15 servings delivers far less than a $95 product providing 500 mg per serving with 45+ servings

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Afamelanotide is authorised as a medicine in certain jurisdictions