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It is derived from guar gum but processed to remove the excessive thickening properties that make regular guar gum impractical as a daily supplement

The commercial window for first-mover C&G therapy developers may therefore extend well beyond the 12-year BPCIA reference product exclusivity period, simply because the regulatory pathway for competition does not yet exist in operational terms

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semaglutide accelerates this process in some individuals

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For this reason, EASL guidelines suggest prudentially an individualized follow-up every three years for asymptomatic family members and first-degree relatives of heterozygous parents with severe MDR3 deficiency, even if they have normal laboratory values and no signs of advanced liver fibrosis or gallstone disease [68]