HIV protease inhibitorsritonavir, indinavir, saquinavir, nelfinavir, and zidovudinewere described as ABCC1 substrate [35], suggesting that the overexpression of ABCC1 in infected cells makes these cells more resistant to chemotherapy
Further confirming this is the elevated amounts of 1,3-diaminopropane, a naturally occurring polyamine, that functions as a byproduct of polyamine degradation 88 , and contributes to the production of metabolites such as beta ()-alanine, which is involved in pyrimidine metabolism 89
Glutathione Dysregulation and the Etiology and Progression of Human Diseases. Biological chemistry 390.3 (2009): 191214
Detoxification of vinyl carbamate epoxide by glutathione: evidence for participation of glutathione S-transferases in metabolism of ethyl carbamate
10.1016/j.jaci.2005.12.1331 101 GuH.AnH.-J.KimJ.-Y.KimW.-H.GwonM.-G.KimH.-J.et al (2019)
NAD+ (nicotinamide adenine dinucleotide) is a coenzyme found in every cell in the body that plays a central role in cellular energy metabolism and DNA repair processes