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For example, in a thioacetamide-induced mouse model, semaglutide reduced biochemical and histological markers of liver injury, attenuated -SMA expression, decreased oxidative stress, and downregulated the canonical TGF-/Smad signalling pathway while upregulating SIRT1 and phosphorylated AMPK

However, like semaglutide, retatrutide's effect on stomach emptying lessens over time, which might need a break from the drug to restore its effectiveness

decreased Arg1, CD206) but also in absolute cell counts, which not only maintains a chronic inflammatory state but also suppresses angiogenesis and extracellular matrix (ECM) remodeling (Shao et al., 2025