Receptor density and signalling efficiency in the area postrema vary across the 24-hour cycle
Up to 70 percent of women report memory or concentration problems during perimenopause or post-menopause, with brain fog showing up as word-finding trouble, slower recall, and difficulty concentrating
DSIP has paradoxical stability characteristics: it is rapidly degraded by blood enzymes with a half-life of minutes, yet its sleep-normalizing effects persist for days to weeks after administration
When deficiency is diagnosed, lifelong B replacement is often required (especially in pernicious anemia)
Metformin-induced vitamin B12 deficiency can cause or worsen distal symmetrical, autonomic and cardiac neuropathy
Clothes are fitting looser, water retention has improved, energy levels are better