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Once diagnosed, median survival is between 2 and 5 years, although patients with bulbar-onset ALS tend to decline more quickly

doi: 10.1016/j.freeradbiomed.2018.05.074 60 ChenXLiJKangRKlionskyDJTangD

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Patients starting from higher BMI (35+) may see faster initial results, but the rate stabilizes to 12 pounds weekly by month three as metabolic adaptation occurs