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Due to the crackdown, more Americans must choose between shelling out hundreds or thousands of dollars per month for name-brand GLP-1s or stopping the medications altogether (studies show that quitting the drugs often results in significant regain)

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The STEP 1 trial extension, which followed patients for a year after stopping semaglutide, showed participants had regained two-thirds of their lost weight by the end of that year (Stanford Medicine, 2026)

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So, if supplementing is warranted in your case, opt for a methyl- or adenosylcobalamin-containing supplement over one containing cyanocobalamin