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Embedded hydroxy,unsaturated epoxyketone becomes electrophilic only inside the enzyme, acting as a solubilityswitching warhead
coverage is more common for Type 2 diabetes diagnoses
Administered GLP-1(28-36)amide for 20 min to male C57BL6/J mice (10-12 week old), then isolated hearts underwent 30 min of global ischemia and 40 min of reperfusion, the recovery of left ventricular developed pressure (LVDP) is significantly greater in GLP-1(28-36)amide group compared to vehicle-treated hearts [1]
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