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An oral GLP-1 pill is also likely easier to mass produce than injectable versions, which could prevent or limit the risk of widespread shortages that regularly affected semaglutide and tirzepatide in the first years of approval

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Medications that require rapid absorption may need to be taken at different times

10.1007/s12325-022-02153-x 42 KangX.WangD.ZhangL.HuangT.LiuS.FengX.et al (2023)