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Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice

26 However, in a 5-year follow-up of a subset of these patients without hypertension at the start of the study, there was no association between the development of hypertension and sleep apnea after accounting for body mass index (BMI), suggesting this association may instead be caused by obesity

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And they do all of this without requiring the extreme calorie restriction that would compromise milk supply or recovery

Both bypass the gut, so both produce strong serum levels