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The generation of ROS plays the role of indirect damage to tumor cells, and this is observed in a large portion of DNA damage caused by low linear energy transfer radiation, such as X- and gamma-rays 13,14 Thus, ROS is an important factor in controlling tumor cell radio-resistance 15 To counteract ROS production and survive radiation therapy, radio-resistant tumor cells maintain increased levels of reductants, such as GSH, which protect cells from oxidative damage through reaction with electrophiles or ROS 6,16,17

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Enhanced bioavailability: black pepper extract increases the bioavailability of berberine and white mulberry by 30%**