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Think of it as the opposite of insulin, a hormone that lowers blood sugar levels
These concerns kept GIP on the back burner for years while GLP-1 took center stage in drug development
They used AlphaFold2 to predict the structure of the original sensor, removed the unstructured linker computationally, and reoriented Grx1 to align the GSSG binding site with the reactive cysteines of roGFP2
These include BPC-157, TB-500, KPV, MOTs-C, Emideltide, Semax, and Epitalon