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Furthermore, the autophagy enhancer rapamycin inhibits the mTOR pathway, upregulates the expression of LC3- and Beclin-1, triggers autophagy, facilitates the aggregation of PMF, and improves the survival rate of oocytes (Sun et al., 2018)
A disrupted barrier can result from over-cleansing, using harsh skincare products, nutritional deficiencies (especially in zinc, vitamin A, and omega-3 fatty acids), and gut imbalances
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